Department Publications

Objective The Temporal Response Function (TRF) is a linear model of neural activity time-locked to continuous stimuli, including continuous speech. TRFs based on speech envelopes typically have distinct components that have provided remarkable insights into the cortical processing of speech. However, current methods may lead to less than reliable estimates of single-subject TRF components. Here, we compare two established methods, in TRF component estimation, and also propose novel algorithms that utilize prior knowledge of these components, bypassing the full TRF estimation. Methods We compared two established algorithms, ridge and boosting, and two novel algorithms based on Subspace Pursuit (SP) and Expectation Maximization (EM), which directly estimate TRF components given plausible assumptions regarding component characteristics. Single-channel, multi-channel, and source-localized …

Stroke patients with hemiparesis display decreased beta band (13–25 Hz) rolandic activity, correlating to impaired motor function. However, clinically, patients without significant weakness, with small lesions far from sensorimotor cortex, exhibit bilateral decreased motor dexterity and slowed reaction times. We investigate whether these minor stroke patients also display abnormal beta band activity. Magnetoencephalographic (MEG) data were collected from nine minor stroke patients (NIHSS < 4) without significant hemiparesis, at ~1 and ~6 months postinfarct, and eight age-similar controls. Rolandic relative beta power during matching tasks and resting state, and Beta Event Related (De)Synchronization (ERD/ERS) during button press responses were analyzed. Regardless of lesion location, patients had significantly reduced relative beta power and ERS compared to controls. Abnormalities persisted over visits, and were present in both ipsi- and contra-lesional hemispheres, consistent with bilateral impairments in motor dexterity and speed. Minor stroke patients without severe weakness display reduced rolandic beta band activity in both hemispheres, which may be linked to bilaterally impaired dexterity and processing speed, implicating global connectivity dysfunction affecting sensorimotor cortex independent of lesion location. Findings not only illustrate global network disruption after minor stroke, but suggest rolandic beta band activity may be a potential biomarker and treatment target, even for minor stroke patients with small lesions far from sensorimotor areas.

Primary auditory cortex is a critical stage in the human auditory pathway, a gateway between subcortical and higher-level cortical areas. Receiving the output of all subcortical processing, it sends its output on to higher-level cortex. Non-invasive physiological recordings of primary auditory cortex using electroencephalography (EEG) and magnetoencephalography (MEG), however, may not have sufficient specificity to separate responses generated in primary auditory cortex from those generated in underlying subcortical areas or neighboring cortical areas. This limitation is important for investigations of effects of top-down processing (e.g., selective-attention-based) on primary auditory cortex: higher-level areas are known to be strongly influenced by top-down processes, but subcortical areas are often assumed to perform strictly bottom-up processing. Fortunately, recent advances have made it easier to isolate the neural activity of primary auditory cortex from other areas. In this perspective, we focus on time-locked responses to stimulus features in the high gamma band (70–150 Hz) and with early cortical latency (∼40 ms), intermediate between subcortical and higher-level areas. We review recent findings from physiological studies employing either repeated simple sounds or continuous speech, obtaining either a frequency following response (FFR) or temporal response function (TRF). The potential roles of top-down processing are underscored, and comparisons with invasive intracranial EEG (iEEG) and animal model recordings are made. We argue that MEG studies employing continuous speech stimuli may offer particular benefits, in that …

Stroke patients with hemiparesis display decreased beta band (13–25Hz) rolandic activity, correlating to impaired motor function. However, clinically, patients without significant weakness, with small lesions far from sensorimotor cortex, exhibit bilateral decreased motor dexterity and slowed reaction times. We investigate whether these minor stroke patients also display abnormal beta band activity. Magnetoencephalographic (MEG) data were collected from nine minor stroke patients (NIHSS< 4) without significant hemiparesis, at~ 1 and~ 6 months postinfarct, and eight age-similar controls. Rolandic relative beta power during matching tasks and resting state, and Beta Event Related (De) Synchronization (ERD/ERS) during button press responses were analyzed. Regardless of lesion location, patients had significantly reduced relative beta power and ERS compared to controls. abnormalities persisted over visits, and were present in both ipsi-and contra-lesional hemispheres, consistent with bilateral impairments in motor dexterity and speed. Minor stroke patients without severe weakness display reduced rolandic beta band activity in both hemispheres, which may be linked to bilaterally impaired dexterity and processing speed, implicating global connectivity dysfunction affecting sensorimotor cortex independent of lesion location. Findings not only illustrate global network disruption after minor stroke, but suggest rolandic beta band activity may be a potential biomarker and treatment target, even for minor stroke patients with small lesions far from sensorimotor areas.

Diagnosing pre-existing heart diseases early in life is important as it helps prevent complications such as pulmonary hypertension, heart rhythm problems, blood clots, heart failure and sudden cardiac arrest. To identify such diseases, phonocardiogram (PCG) and electrocardiogram (ECG) waveforms convey important information. Therefore, effectively using these two modalities of data has the potential to improve the disease screening process. We evaluate this hypothesis on a subset of the PhysioNet Challenge 2016 Dataset which contains simultaneously acquired PCG and ECG recordings. Our novel dual-convolutional neural network based approach uses transfer learning to tackle the problem of having limited amounts of simultaneous PCG and ECG data that is publicly available, while having the potential to adapt to larger datasets. In addition, we introduce two main evaluation frameworks named record-wise …

Cortical processing of arithmetic and of language rely on both shared and task-specific neural mechanisms, which should also be dissociable from the particular sensory modality used to probe them. Here, spoken arithmetical and non-mathematical statements were employed to investigate neural processing of arithmetic, compared with general language processing, in an attention-modulated cocktail party paradigm. Magnetoencephalography (MEG) data were recorded from 22 human subjects listening to audio mixtures of spoken sentences and arithmetic equations while selectively attending to one of the two speech streams. Short sentences and simple equations were presented diotically at fixed and distinct word/symbol and sentence/equation rates. Critically, this allowed neural responses to acoustics, words, and symbols to be dissociated from responses to sentences and equations. Indeed, the simultaneous …

Cortical processing of arithmetic and of language rely on both shared and task-specific neural mechanisms, which should also be dissociable from the particular sensory modality used to probe them. Here, spoken arithmetical and non-mathematical statements were employed to investigate neural processing of arithmetic, compared to general language processing, in an attention-modulated cocktail party paradigm. Magnetoencephalography (MEG) data were recorded from 22 human subjects listening to audio mixtures of spoken sentences and arithmetic equations while selectively attending to one of the two speech streams. Short sentences and simple equations were presented diotically at fixed and distinct word/symbol and sentence/equation rates. Critically, this allowed neural responses to acoustics, words, and symbols to be dissociated from responses to sentences and equations. Indeed, the simultaneous neural processing of the acoustics of words and symbols were observed in auditory cortex for both streams. Neural responses to sentences and equations, however, were predominantly to the attended stream, originating primarily from left temporal, and parietal areas, respectively. Additionally, these neural responses were correlated with behavioral performance in a deviant detection task. Source-localized Temporal Response Functions revealed distinct cortical dynamics of responses to sentences in left temporal areas and equations in bilateral temporal, parietal, and motor areas. Finally, the target of attention could be decoded from MEG responses, especially in left superior parietal areas. In short, the neural responses to arithmetic …

Our ability to communicate using speech depends on complex, rapid processing mechanisms in the human brain. These cortical processes make it possible for us to easily understand one another even in noisy environments. Measurements of neural activity have found that cortical responses time-lock to the acoustic and linguistic features of speech. Investigating the neural mechanisms that underlie this ability could lead to a better understanding of human cognition, language comprehension, and hearing and speech impairments.

Neural processing along the ascending auditory pathway is often associated with a progressive reduction in characteristic processing rates. For instance, the well-known frequency-following response (FFR) of the auditory midbrain, as measured with electroencephalography (EEG), is dominated by frequencies from ∼100 Hz to several hundred Hz, phase-locking to the acoustic stimulus at those frequencies. In contrast, cortical responses, whether measured by EEG or magnetoencephalography (MEG), are typically characterized by frequencies of a few Hz to a few tens of Hz, time-locking to acoustic envelope features. In this study we investigated a crossover case, cortically generated responses time-locked to continuous speech features at FFR-like rates. Using MEG, we analyzed responses in the high gamma range of 70–200 Hz to continuous speech using neural source-localized reverse correlation and the …

Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be responsible. Nine patients with recent minor strokes and eight age-similar controls underwent cognitive screening using the Montreal cognitive assessment (MoCA) and MEG to evaluate differences in cerebral activation patterns. During MEG, subjects participated in a visual picture–word matching task. Task complexity was increased as testing progressed. Cluster-based permutation tests determined differences in activation patterns within the visual cortex, fusiform gyrus, and lateral temporal lobe. At visit 1, MoCA scores were significantly lower for patients than controls (median [interquartile range …

We consider the problem of determining Granger causal influences among sources that are indirectly observed through low-dimensional and noisy linear projections. Commonly used methods proceed in a two-stage fashion, by first solving an inverse problem to localize the sources, and then inferring the Granger causal influences from the estimated sources. The inferred Granger causal links thus inherit the various biases that are used in source localization techniques, in the form of spatiotemporal priors designed in favor of spatial localization. In addition, this approach does not account for the structural properties of the underlying functional networks such as sparsity of the links. We address these issues by modeling the source dynamics as sparse vector autoregressive processes and estimate the model parameters directly from the observations, with no recourse to intermediate source localization. We evaluate …

Light field saliency detection—important due to utility in many vision tasks—still lack speed and can improve in accuracy. Due to the formulation of the saliency detection problem in light fields as a segmentation task or a “memorizing” tasks, existing approaches consume unnecessarily large amounts of computational resources for (training and) testing leading to execution times is several seconds. We solve this by aggressively reducing the large light-field images to a much smaller three-channel feature map appropriate for saliency detection using an RGB image saliency detector. We achieve this by introducing a novel convolutional neural network based features extraction and encoding module. Our saliency detector takes 0.4 s to process a light field of size 9× 9× 512× 375 in a CPU and is significantly faster than existing systems, with better or comparable accuracy. Our work shows that extracting features from light fields through aggressive size reduction and the attention results in a faster and accurate light-field saliency detector.

In Electroencephalography (EEG) classifiers, processing of EEG signals consists of extracting features from EEG signal and then processing those features to classify the signals. As of today, in most EEG processing systems, the classification part is done on software platform even though the feature extraction is done on hardware. Hence this require an operating system which limits the development of portable medical devices. This paper presents the design and implementation of feature classification in EEG signal processing system on Field Programmable Gate Array (FPGA) hardware platform. The classification is done with two-class Linear Discriminant Analysis (LDA), based on the features extracted using Discrete Wavelet Transform (DWT), for EEG signals obtained through PhysioNet website. The final design has minimum resource utilization, hence is able to implement on Basys 3 Artix-7 FPGA Board …

Eelbrain - ADS Now on home page ads icon ads Enable full ADS view ADS Eelbrain Brodbeck, Christian ; Das, Proloy ; Brooks, Teon L ; Reddigari, Samir ; jpkulasingham Abstract No description provided. Publication: Zenodo Pub Date: DOI: 10.5281/zenodo.7951251 Bibcode: 2023zndo...7951251B full text sources Zenodo | Related Materials (2) Version 0.36 Version v0.32 © The SAO Astrophysics Data System adshelp[at]cfa.harvard.edu The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement 80NSSC21M0056 Smithsonian logo Harvard Center for Astrophysics logo NASA logo *The material contained in this document is based upon work supported by a National Aeronautics and Space Administration (NASA) grant or cooperative agreement. Any opinions, findings, conclusions or recommendations expressed in this material are those of the author and do not …

Neural processing along the ascending auditory pathway is often associated with a progressive reduction in characteristic processing rates. For instance, the well-known frequency-following response (FFR) of the auditory midbrain, as measured with electroencephalography (EEG), is dominated by frequencies from~ 100 Hz to several hundred Hz, phase-locking to the stimulus waveform at those frequencies. In contrast, cortical responses, whether measured by EEG or magnetoencephalography (MEG), are typically characterized by frequencies of a few Hz to a few tens of Hz, time-locking to acoustic envelope features. In this study we investigated a crossover, cortically generated responses time-locked to continuous speech features at FFR-like rates. Using MEG, we analyzed high-frequency responses (70-300 Hz) to continuous speech using neural source-localized reverse correlation and its corresponding temporal response functions (TRFs). Continuous speech stimuli were presented to 40 subjects (17 younger, 23 older adults) with clinically normal hearing and their MEG responses were analyzed in the 70-300 Hz band. Consistent with the insensitivity of MEG to many subcortical structures, the spatiotemporal profile of these response components indicated a purely cortical origin with~ 40 ms peak latency and a right hemisphere bias. TRF analysis was performed using two separate aspects of the speech stimuli: a) the 70-300 Hz band of the speech waveform itself, and b) the 70-300 Hz temporal modulations in the high frequency envelope (300-4000 Hz) of the speech stimulus. The response was dominantly driven by the high frequency …

This paper presents a novel low-complexity VLSI architecture for an EEG Feature Extraction Platform for wearable health monitoring systems. It integrates a processing core unit, preprocessing FIR filter block and an FFT accelerator. The platform supports 8 scalp EEG channels and it can be scaled up to 16 or 32 EEG channels. In this paper, we analyze several architectural optimizations for hardware implementation of features such as Power Spectral Density, Discrete Wavelet Transform, Autoregression etc. The proposed architecture is easily scalable to new feature extractors. An FFT accelerator is proposed to improve the flexibility of the platform. We provide a comparison with software models for each feature extractor and also validate the platform by implementing a seizure detection algorithm on CHB-MIT Scalp EEG database with an accuracy of over 95%.

Pulse Transit Time (PTT)/Pulse Wave Velocity (PWV) measurement based non-invasive blood pressure estimation is of much interest at present, as it enables continuous monitoring of blood pressure in a more comfortable manner compared to traditional cuff based methods, without hindering natural user behavior. In this study we have investigated the possibility of estimating blood pressure using PTT without the need of external calibrations. The parametric model developed in our previous research is improved eliminating the need of initial calibration which requires external blood pressure measurement from a reference device. The results suggest that there is a potential of developing calibrationless blood pressure estimation methods based on PTT/PWV which may require further testing and validation.

The P300 wave is an Event Related Potential that is elicited in the brain when a subject is presented with a familiar stimulus. The Guilty Knowledge Test is used to determine if certain information is stored in the brain by detecting the P300 wave. In this paper, an improved Guilty Knowledge Test has been conducted on 14 subjects. Although a variety of feature extraction and classification algorithms for detecting the P300 have been used thus far, this paper introduces the use of deep learning techniques for the Guilty Knowledge Test. Two deep learning techniques; Deep Belief Networks and Stacked Autoencoders, have been compared. The input to these classifiers was the filtered EEG signal without any feature extraction. A mean accuracy of 86.9% was achieved for the Deep Belief Network and 86.01% for the Stacked Autoencoder on our dataset, outperforming the conventional Support Vector Machine.

The P300 Speller is a Brain Computer Interface that enables communication using the EEG signal. The P300 wave is an Event Related Potential that occurs as a response to a familiar stimulus. This system can be used to aid persons who are unable to communicate via conventional methods. In this paper, the P300 Speller has been modified to allow communication in three languages: English, Sinhala and Tamil. Classification of the P300 waveform was done using an ensemble of Support Vector Machines. A mean letter classification accuracy of 83.76% and a mean P300 classification accuracy of 90.68% was achieved on our dataset.

Brain-computer interfaces (BCIs) require real-time feature extraction for translating input EEG signals recorded from a subject into an output command or decision. Owing to the inherent difficulties in EEG signal processing and neural decoding, many of the feature extraction algorithms are complex and computationally demanding. Presently, software does exist to perform real-time feature extraction and classification of EEG signals. However, the requirement of a personal computer is a major obstacle in bringing these technologies to the home and mobile user affording ease of use. We present the FPGA design and novel architecture of a generalized platform that provides a set of predefined features and preprocessing steps that can be configured by a user for BCI applications. The preprocessing steps include power line noise cancellation and baseline removal while the feature set includes a combination of linear …

Early detection of hypertension generally requires continuous monitoring of blood pressure levels which is not facilitated by traditional methods such as the cuff, which cannot be used in the normal environment for continuous monitoring due to the regular pressurization of certain body parts. Thus there is a need for non-invasive continuous pressure monitoring mechanism. In this paper we present a relationship between Pulse Transit Time (PTT) and Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) for continuous pressure monitoring and its experimental validation.

Brain-Computer Interaction (BCI) is a technology developed with the purpose of building a pathway between the brain and computer which is independent of neuromuscular functions. Potential applications in rehabilitation of patients with motor disabilities and video gaming make BCI an important field of research. A task like controlling a prosthetic limb using BCI is challenging. Performing this with readily available consumer grade EEG devices complicates the matters further due to lower accuracies. This paper presents the work related to an online classifier for imagined hand movement implemented using Emotiv Epoc for EEG data capturing. The system attempts to discriminate between left and right hand movement imagination by analysing the recordings of two electrodes placed over the motor-cortex. Auto-Regression (AR) based signal processing techniques are employed to derive features that enable …

Listening to the heart sounds is a common practice in identifying cardiac malfunctions. Since this method has many limitations, tools that aid physicians in their diagnosis of heart diseases are very useful. This paper presents a software tool to predict cardiac abnormalities which can be identified using heart sounds. Both heart sound information and symptoms are used in disease prediction. First audio inputs at four clinically important locations on the chest are acquired using an electronic stethoscope and entered to a database with symptoms for each patient. After de-noising, prominent features and statistical parameters needed for disease detection are extracted from the heart sound samples using several algorithms. Then the disease classification is performed to find out possible disease and murmur types. The software tool reported in this paper is capable of identifying normal heart sounds and abnormal heart …